MARCOIL is a hidden MARkov model-based program that
predicts existence and location of potential coiled-coil
domains in protein sequences.
An exact description of the model is in preparation and
should soon be submitted for publication preliminary version
was presented as a poster at ISMB2000.
The utility of a prediction program is often best judged
by experience gathered in using it and we would welcome
comments or suggestion for improvements.
The code can be downloaded here:
It was tested under UNIX and LINUX and can be compiled
using the included makefile that calls the gcc compiler. A
file with Instructions for Installation and Usage is
included in the distribution and can be read online:
For testing a database of positive examples with
annotated coiled-coils (
databasePD.gz ) and a database of sequences from PDB
databaseND.gz ), from which coiled-coils were
eliminated, have been used. Lines that begin with a "<"
contain information on the sequence like accession number or
identifier or additional information. Lines that begins with
a ">" contain the coiled-coil annotation we used (the
number of domains followed by first and last position of
each domains). This line is followed by the protein
For questions and comments:
Homepage Mauro Delorenzi
Our historical Web-Interface to Marcoil
Web-Interface to Marcoil at Dept. of Max Planck Institute for Developmental Biology Tübingen